Article du Bulletin
A pre-S/S CHO-derived hepatitis B virus vaccine protects woodchucks from WHV productive infection.
Argentini C., Giuseppetti R., D'Ugo E., La Sorsa V., Tritarelli E., Orobello S., Canitano A., Gluck R. & Rapicetta M. · 2005 · Vaccine, 23(28): 3649-56.
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Résumé
We evaluated whether a non-adjuvanted vaccine derived from Chinese hamster ovary cells was capable of providing protection against woodchuck hepatitis virus (WHV). Three woodchucks were vaccinated with four 50-microg doses and challenged with a previously characterized virus isolate (WHV197). In all three animals, titre levels of antibodies against hepatitis B surface antigens (anti-HBs) exceeded 10 mIU/ml, peaking at 150 mIU/ml. Challenge resulted in productive acute infection in the two non-vaccinated woodchucks yet in none of the vaccinated woodchucks. In the vaccinated animals, there was evidence of abortive infection. The results demonstrate that a human vaccine is able to protect woodchucks from WHV infection.