Article du Bulletin
[Étude sur le génotype et la microévolution de Yersinia pestis sur le plateau du Tibet. Study on the genotyping and microevolution of Yersinia pestis in the Qinghai-Tibet Plateau]
Li M., Dai E.H., Dai R.X., Zhou D.S., Yang X.Y., Cui B.Z., Jin L.X., Zhao H.H., Li C.X., Qi M.Y., Ci Ren D.Z., Dai X., Tang Y.J. & Yang R.F. · 2006 · Zhonghua Liu Xing Bing Xue Za Zhi, 27(5): 412-415.
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Résumé
OBJECTIVE: To study the distribution of genomovars and microevolution of Yersinia pestis in the Qinghai-Tibet Plateau. METHODS: Primer pairs targeting the twenty-two different regions(DFRs) were designed for detecting the presence or deletion of each DFR in 297 strains isolated from the Qinghai-Tibet Plateau. RESULTS: 9 genomovars, i. e. Genomovar 1, 5, 6, 7, 8, 10, 11, new type and Ype-ancestor were identified in the Marmota himalayana plague focus of the Qinghai-Tibet Plateau. Among these genomovars, genomovar 5,8 and 10 were dominant types. The total rate of the three genomovars was 80.6% (204/253) and the genomovars in different regions were different. All of 44 strains of Y. pestis in the Microtus fuscus plague focus of the Qinghai-Tibet Plateau belonged to genomovar 14. CONCLUSION: The distribution of genomovars of Y. pestis in the Qinghai-Tibet plateau had remarkable characteristics geographically. Based on the distribution of genomovars of Y. pestis, the routes of transmission and microevolution of Y. pestis were proposed.