Article du Bulletin
Potential of 2,4-dichlorophenoxyacetic acid conjugates as promutagens in the Salmonella/microsome mutagenicity test.
Rashid K.A., Babish J.G. & Mumma R.O. · 1984 · J. Environ. Sci. Health B., 19(8-9): 689-701.
Résumé
Hepatic S9 preparations from Aroclor 1254 induced rats and 3-methylcholanthrene induced woodchucks were used to investigate, in vitro, the mutagenic potential of five amino acid conjugates of 2,4-Dichlorophenoxyacetic acid (alanine, aspartic acid, leucine, methionine and tryptophan). Five strains of Salmonella typhimurium (TA97, TA98, TA100, TA1535, TA1538) were utilized for this purpose. Dose-response effects producing a two-fold increase of revertants over spontaneous levels were not observed with either S9 preparation indicating that the amino acid conjugates are not promutagens in these assays.