Parameters of oxygen delivery in the species Marmota flaviventris at sea level and 12.000 feet. [Paramètres du débit d'oxygène chez Marmota flaviventris au niveau de la mer et à 3600 m].

Résumé

Hemoglobin, hematocrit, 2, 3-DPG, O2 dissociation curve and plasma pH changes were evaluated in the high altitude native mammal, Marmota flaviventris (yellow-bellied marmot), acclimatized to an altitude of 840 ft for l year. They were then placed in hypobaric chambers at l 2,000 + 500 ft for 5 days and the same parameters again studied. Increases in all parameters were statistically significant except plasma pH. It is suggested that this animal should be considered a natural paradigm for further laboratory biochemical, physiological and pharmacological studies of oxygen conductance, under conditions of hypoxic stress.