A report on studies with Marmota monax. I. -Biochemical and pharmacological investigations of blood and brown fat [Rapport sur l’étude de M. monax. I. Recherches biochimique et pharmacologique sur le sang et la graisse brune].

Résumé

1. A brief outline is given of nine years’ research designed to extract a biologically active substance from hibernating animals, related to the phenomenon of hibernation. 2.Testing for physiological activity is based on the premise that such a substance would increase the tolerance to low body temperature of non hibernating test animals. 3. Although minimal positive results have been obtained on occasion, no really reliable evidence of such a humoral agent has yet been found. 4. The reason why this team adhered to the humoral theory of hibernation are given.