Article du Bulletin
Quantitative Evaluation of 2-Deoxy-2[F-18]fluoro-D: -glucose-Positron Emission Tomography Imaging on the Woodchuck Model of Hepatocellular Carcinoma with Histological Correlation.
Salem N., Maclennan G.T., Kuang Y., Anderson P.W., Schomisch S.J., Tochkov I.A., Tennant B.C & Lee Z. · 2007 · Molecular imaging and biology (Mol. Imaging Biol.), 9(3): 135-43.
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Résumé
The Eastern woodchuck (Marmota monax) is considered as a naturally occurring animal model of hepatocellular carcinoma (HCC). The performance of 2-deoxy-2-[F-18]fluoro-D: -glucose (FDG) for imaging HCC on the woodchuck using Positron emission tomography (PET) was investigated in this study. Dynamic FDG-PET scans were performed on five woodchucks with HCC and one healthy woodchuck before removal and processing of the liver tissues for histology. The parameters of a two-tissue compartment model with dual input were estimated using weighted least squares (WLS). Ten HCCs were confirmed histologically. Six HCCs had a tumor-to-liver standardized uptake value (SUV) ratio 1.15, a lower k (4) / k (3) ratio than the hepatic tissues and were moderately differentiated. Increased FDG uptake was observed in HCCs that were the least differentiated and correlated with a lower k (4) / k (3) ratio.