Article du Bulletin
Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks.
Casey J., Cote P.J., Toshkov I.A., Chu C.K., Gerin J.L., Hornbuckle W.E., Tennant B.C. & Korba B.E. · 2005 · Antimicrobial agents and chemotherapy (Antimicrob. Agents Chemother.), 49(10): 4396-4399.
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Résumé
In a small controlled study, clevudine, a potent inhibitor of hepadnaviruses, including hepatitis B virus and woodchuck hepatitis virus, suppressed hepatitis delta virus (HDV) viremia in chronically infected woodchucks. Suppression was correlated with the marked reduction of woodchuck hepatitis virus surface antigen in individual animals, consistent with the concept that repression of surface antigen expression may be a useful antiviral strategy for HDV.